2bind GmbH
Booth number: 180-01
www.2bind.com
About us
2bind is the expert contract research organization (CRO) for biophysical analytics. Since 2011 we have successfully completed over 1700 tasks in contract research projects with > 450 different customers from biotech, pharma, and academia.
2bind serves customers/clients working in protein- and RNA-focussed drug discovery, antibody development and protein formulation.
We bring together passionate scientists from different life-science backgrounds to catalyze our clients’ research and development projects.
With a portfolio of 16 biophysical methods, 2bind can answer practically every question for binding affinity, kinetics, thermodynamics, stoichiometry as well as molecular parameters such as protein stability, unfolding, buffer optimum, radius, polydispersity index and many more. Our scalable assay format cover comprehensive but also HTS capable formats.
Work with the experts in biophysics!
Address
Im Gewerbepark D19a
93059 Regensburg
Germany
E-mail: info@2bind.com
Phone: +49 941 20000890
Internet: www.2bind.com
Contact person:
Products & Services
Overview on 2bind´s biophysical analytical services for:
Protein focussed Drug Discovery
RNA focussed Drug Discovery
Fragment based Drug Discovery
PROTAC / GLUE / Degrader Development
Antibody Developability and Pre-formulation
Biophysics for Small molecule based Drug Discovery from HIT ID to Hit to lead
2bind offers biophysical outsourcing solutions for small molecule based Drug Discovery:
HIT ID biophysical high throughput screening with methods MST; Spectral Shift, GCI, nanoDSF supported by LabCyte Echo
HIT Validation Orthogonal biophysical assays to validate HITs using methods such as MST; Spectral Shift, GCI, nanoDSF, Helix, ITC
HIT to lead Biophysical MedChem support with methods such as MST; Spectral Shift, GCI, nanoDSF, Helix, ITC
Biophysics for Antibody Research: Characterisation of AB-AG Interactions, Developability studies, Formulation
Antibody Research Services:
We offer assays in
Early Antibody Discovery with focus on interaction analyses:
- Off rate ranking
- Lgand Screening
- Kinetic characterisation of AB-AG interactions
- Affinity analysis in solutions (possible even in bioliquids such as serum, plasma, mucose, urine....)
- Kinetics on living cells (RT-IC)
- Characterisation of Bi-Specifics
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Developability Studies:
- thermal stability
- colloidal stability (polydispersity)
- charge
- size
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Formulation and long term storage optimisation:
- Buffer and detergent screening
- FDA Plate ™(Formulations of Developed Antibodies is a buffer library of 96 buffers of FDA or EMA approaved ABs with benefitial influence on protein stability and aggregation tendency) Test your AB in buffer conditions of approved AB drugs
- Design of Experiment (DoE) based Formulation
- Long-term storage optimization assays
- Forced degradation assays
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Other services
- Comparison of biosimilars to originators
- ADC characterization
Biophysics for Fragment based Drug Discovery from HIT ID to Hit to lead
2bind offers biophysical outsourcing solutions for small molecule based Drug Discovery:
HIT ID
biophysical high throughput screening with methods MST; Spectral Shift, GCI, nanoDSF supported by LabCyte Echo
HIT Validation
Orthogonal biophysical assays to validate HITs using methods such as MST; Spectral Shift, GCI, nanoDSF, Helix, ITC
HIT to lead
Biophysical MedChem support with methods such as MST; Spectral Shift, GCI, nanoDSF, Helix, ITC
2bind posesses 3 fragment libraries (1940 for direct binding to proteins and 3600 for PPI projects and a sophisticated 800 molecule library from Spirochem). We can also work with external libraries