PEPperPRINT GmbH
Booth number: 180-24
www.pepperprint.com
About us
PEPperPRINT is the leading provider of high-density peptide microarrays and related antibody and protein services. From pre-designed off-the-shelf peptide microarrays, to customized contract research solutions, PEPperPRINT offers a wide range of products and services for a variety of research applications. Based on its proprietary laser-printing technology, PEPperPRINT can synthesize tens of thousands of peptides directly on the chip with a unique flexibility in terms of custom peptide content, a high spot density, and reduced material consumption. The product and service portfolio was recently complemented by T cell epitope mapping and monitoring, making PEPperPRINT a one-stop solution provider for the fingerprint analysis of immune responses e.g. for epitope mapping, antibody biomarker discovery or the analysis of adverse immune effects.
PEPperPRINT’s peptide microarrays and screening services have been used by researchers around the world with over 250 peer-reviewed publications.
Address
Tullastraße 2
69126 Heidelberg
Germany
E-mail: info@pepperprint.com
Phone: +49 6221 7264488
Internet: www.pepperprint.com
Contact person:
PEPperMAP® Epitope Mapping
Identify linear or conformational epitopes with amino acid resolution. Based on high-density peptide microarrays with linear or cyclic constrained peptides for conformational analyses, our PEPperMAP® Epitope Mapping Services enable the fingerprint analysis of antibody epitopes. Underlined by more than 200 peer-reviewed publications, we provide the fastest and most cost-effective way to obtain high resolution epitope data.
PEPperMAP® Antibody Validation
We validate the binding specificity of your antibody by an all-in-one analysis package including a high-resolution PEPperMAP® Epitope Mapping, a subsequent PEPperMAP® Epitope Substitution Scan to identify conserved and variable amino acid positions and a PEPperMAP® Antibody Cross-Reactivity Profiling.
T Cell Epitope Mapping
T cells are activated upon contact with other cells that present an appropriate peptide-MHC complex. The immunogenicity of the peptides is thereby restricted by their binding motives to different MHC proteins among individuals. At PEPperPRINT, we set up a peptide library by converting the original protein into overlapping peptides, and analyzing the peptide immunogenicity with a combination of peptide-MHC binding prediction tools and validation assays such as ELISpot.
Anti-Drug Antibody Analysis
Protein or antibody drug immunogenicity results in the generation of anti-drug antibodies (ADAs), which can reduce drug efficacy, neutralize therapeutic effects or even cause severe immune adverse events to the patient. We provide the fingerprint analysis of anti-drug antibody responses on the epitope level with high-density peptide microarrays based on your protein drug of interest for patient stratification, drug optimization or the development of companion diagnostics.
Fingerprint Analysis of Immune Adverse Effects
Monitor pre-existing and drug-related antibody and T cell responses for immune adverse effect risk assessment. We provide the fingerprint immunogenicity analysis of your antibody or protein drug in a single assay with epitope mapping technology, including T cell services to determine the presence of mAb-reactive T cells in patient PBMCs by ELISpot. This dual strategy enables comparison of the immune landscape among patients with and without adverse effects.
