Numaferm GmbH
About us
The biotechnology company Numaferm was established in 2017 at the University of Düsseldorf and has swiftly emerged to a global leader in peptide, protein, and peptein production. Operating within a facility exceeding 1,000 sqm in Duesseldorf, Germany, our team comprises over 30 experts working in state-of-the-art laboratories equipped with industry-standard devices and infrastructure.
Our primary focus lies in the recombinant production of peptides and proteins, particularly emphasizing "pepteins" (peptide & proteins) spanning 2 to 600 amino acids. Numaferm has pioneered Numaswitch, a biochemical production platform facilitating swift, scalable, and cost-effective production of these biomolecules in large volumes and with superior quality. The production timeline for these molecules is remarkably short, and it's carried out sustainably.
The diverse spectrum of our clientele, including pharmaceuticals, agriculture, veterinary medicine, generics, and cosmetics, underscores the versatile applications of our products across various sectors. Our mission is unequivocal: to provide unparalleled support tailored to your objectives. We are steadfast in delivering solutions that are timely, cost-effective, scalable, high-quality, and sustainable.
Address
Merowingerplatz 1A
40225 Düsseldorf
Germany
E-mail: Nikita.Bangalore@numaferm.com
Phone: +49 211 975 32900
Internet: numaferm.com/
Contact person:
Products & Services
Numaferm GmbH, introduces a new paradigm in peptein manufacturing with the Numaswitch platform: a fully biotechnological production system enabling the traceless, efficient, and sustainable manufacture of native peptides and proteins.
At the core of this platform is Numacut, a proprietary protease engineered to cleave after nearly all amino acids (except proline), enabling scarless removal of fusion tags and overcoming a longstanding limitation of conventional sequence-specific proteases like TEV. In tandem with Numaferm’s Switchtag technology, this platform allows seamless integration of non-canonical amino acids, high-purity expression, and simplified downstream processing.
Numaswitch offers production timelines of less than 2 weeks, scalability to 100 kg per campaign, and is free from toxic solvents, TFA, and non-sustainable reagents. Compared to traditional chemical synthesis, it delivers CO₂ footprint savings exceeding 90% and cost-of-goods reductions of over 85%, meeting increasing regulatory and environmental expectations.
Numaswitch - A Unique Biochemical Production Platform
The superior biochemical platform for easy and efficient production of peptides, proteins and „pepteins“ (peptides & proteins) ranging from 2 – 600 amino acids. Large-scale and high-quality products regardless of lengths and properties (e.g. disulfide-bridges).
Numacut Protease - first protease platform for scarless fusion protein cleavage
The Numacut® TEV protease is the first platform capable of producing native proteins without leaving any additional residues. A new recognition site enables Numacut® to cleave target peptides or proteins fused to a C-terminal, independent of the N-terminal amino acid, without leaving additional residues.