Profil is the world’s leading CRO in metabolic research. As a full-service provider, we conduct early phase clinical trials within the indications of obesity, (pre)diabetes, and diabetes complications. We offer an unrivaled combination of science and professional conduct. This unique combination allows us to design and carry out best-in-class clinical trials for our clients. Our in-house scientific expertise covers pharmacology, obesity and prediabetes, nutritional sciences, cardiometbolic research, hepatology, endocrinology, the entire spectrum of diabetes complications, cell and molecular biology as well as metabolic monitoring and medical technology. One of our core technologies is the hyperinsulinemic euglycemic clamp, used to address action profiles of insulin and insulin analogues, beta cell function and insulin sensitivity. To address human metabolic pathways glucose clamp studies are combined with isotope dilution techniques and tissue biopsies. To be able to offer the best services for any glucose clamping setup, we have developed ClampArt, the next generation of glucose clamping, fully-automated for precise results. By owning a continuously updated database with entries of more than 30.000 well characterized individuals (healthy, healthy at-risk, type 1 and type 2 diabetes), we can recruit even the most complex clinical trials. We have a fully GMP certified pharmacy and in-house clinics with 65 beds and holds expertise in Data Management & Statistics and Regulatory Affairs.