Proteros Drug Discovery Solutions

Qualified hits to unlock challenging drug targets

Enhance your drug discovery programs with the Proteros Discovery Solutions platform delivering hits that unlock even the most technically challenging targets.

Highly successful track record
Flexible access to all the Proteros capabilities under the guidance of a Proteros project manager experienced in early drug discovery
Delivery of Qualified/Advanced Qualified Hits using our range of selected small molecule libraries. Ideal starting points for drug discovery projects.

1. Fragment Library

2. Cluster-based Library

3. Range Finder Library

4. Centroid based library

Cluster Hits qualification by hit verification/characterization, biophysical MOI identification, cellular efficacy testing (if applicable) and full structure enablement
Established enabling technology platform
De-risking of challenging targets
Comprehensive data package

Protein Sciences

Generate the RIGHT protein for the right experiment
Bespoke proteins for Structural Biology or Biochemical screening
Highly experienced team with over 20 years experience
Highly successful service

o Expert Construct Design and Gene Synthesis

o Multiple cell expression systems, to match target criteria and produce at scale:

1. E.coli

2. Yeast

3. Insect

4. Mammalian cells (transient and stable cell pools)

Advanced purification systems to ensure the highest achievable level of purity and activity:
High-quality control for delivery of fit-for-function proteins

o Bespoke Gene-to-Protein Service

o Established Gallery of Protein expression conditions

Biologics

Deliver the right antibody with accurate assembly, purity, structural and biophysical characterization and early developability assessment (non-GxP).

Experienced with a wide variety of biologics formats (bs-Ab, ms-Abs, growth factors, non-human antibody formats and antigens)
Full range of Antibody production capabilities
Analytical profiling of Antibodies
Biophysical evaluation of antibodies
Biologics-x-ray crystallization and Cryo-EM
Development of stable cell pools

X-ray Crystallography

Over 20 years of experience in delivering structural biology projects for small molecule and biologics

Successful track history based upon Nobel prize-winning science
Delivered > 6000 structures
Gallery Structures

Ø >200 relevant targets ready for Protein-Ligand-Structure determination

Ø Cost-efficient with pre-defined protein production, purification, analytics and crystallization conditions

Gene-to-Structure

Ø High-quality service from construct design to structure solution and refinement

Ø High-resolution protein-ligand-structures (PLS) or apo structures

Custom Services

Ø Initial screening, Crystal optimization or Data collection or Structure solution /refinement only

Ø Epitope Binning service

Cryo-EM

Premium cryo-EM platform technology and expertise.
Delivering valuable structural biology information for small molecules, proteins and antibody complexes
Gene-to-Structure and Gallery Structures Services

- 200 relevant targets

Membrane-bound proteins

Assays, Screening and Biophysics

Full biochemical and biophysical characterization of ligand-target interactions for even the most challenging drug discovery projects.
Bespoke assay generation or select from a gallery of >150 targets

Pyrogens

My German Pavilion